Science Behind Microchanneling
How does micro channeling work? Our device punctures the Epidermis (outer layer of the skin) causing tiny micro channels. Each micro channel triggers the body to heal, this process creates new collagen and elastin. When you pair our stem cell rejuvenative serum with this process you will be shocked at the stunning real life results.
Adult Mesenchymal Stem Cells for Tissue Engineering Versus Regenerative Medicine
"This scientific paper by Dr. Arnold Caplan, published in 2007, shows Mesenchymal Stem Cells to be valuable mediators for tissue repair and regeneration. His review summarizes the
biological basis for the functioning of MSCs through development and aging.
MSCs secrete bioactive molecules (growth factors and cytokines) that provide a regenerative microenvironment for a variety of injured adult tissues. They limit the area of damage and help to direct a self-regulated regenerative response.
However, the three orders-of magnitude decrease in MSC numbers between a newborn and an
80-year-old will significantly affect the rate of repair and regeneration."
-Mitchell Schwartz, MD
Revisiting the Skin Health and Beauty Pyramid: A Clinically Based Guide to Selecting Topical Skincare Products
"This scientific paper, published in 2021, nicely shows growth factors and cytokines at the top of
the pyramid for stimulating skin regeneration and is thus an integral part of any skin rejuvenation
program."
-Mitchell Schwartz, MD
Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages
"This scientific paper, published in 2006, showed that intravenously injected MSCs travelled to
hair follicles, sebaceous glands, blood vessels, and the dermis in full-thickness wounds. After
wound healing, many MSCs returned to the bone marrow, and some were retained in the
dermis. The authors concluded “adult MSCs have the capacity to dock at specific sites, to
contribute to wound healing of skin appendages, and to home toward marrow."
-Mitchell Schwartz, MD
Growth factors and cytokines in wound healing
"This scientific paper, published in 2008, dives into the complex, multicellular process involved in wound healing. It discusses the coordinated efforts of keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets and their complex signaling network which involves numerous growth factors and cytokines."
-Mitchell Schwartz, MD
Mesenchymal stem cells induce dermal fibroblast responses to injury
"This scientific paper, published in 2009, showed that bone marrow-derived mesenchymal stem cells provide important early signals for dermal fibroblast responses to cutaneous injury. These responses to injury include fibroblast proliferation, migration and expression of genes important in wound repair."
-Mitchell Schwartz, MD
Efficacy of Microneedling Plus Human Stem Cell Conditioned Medium for Skin Rejuvenation
"This randomized, controlled, blinded split-face study showed the side of the face treated with both growth-factor serum and microneedling had statistically significant greater improvement in wrinkles and pigmentation than the side of the face treated with serum alone."
-Mitchell Schwartz, MD
Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair
"This scientific paper, published in 2004, showed that wound healing involves local cutaneous cells such as fibroblasts for repairing the epidermis, but mesenchymal cells from both distant bone marrow as well as the adjacent, uninjured dermis aid in reconstituting the dermal fibroblast population."
-Mitchell Schwartz, MD
Looking older: fibroblast collapse and therapeutic implications
"This scientific paper, published in 2004, showed that wound healing involves local cutaneous cells such as fibroblasts for repairing the epidermis, but mesenchymal cells from both distant bone marrow as well as the adjacent, uninjured dermis aid in reconstituting the dermal fibroblast population."
-Mitchell Schwartz, MD
Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing
"This scientific paper, published in 2008, showed that bone marrow derived mesenchymal stem cells enhance wound healing by releasing paracrine factors, cytokines and chemokines, which are known to be important in healing compared to those released by dermal fibroblasts. In a mouse model of excisional wound healing, concentrated bone marrow derived mesenchymal stem cells accelerated wound healing compared to fibroblast only conditioned medium."